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Article

β-Catenin is central to DUX4-driven network rewiring in facioscapulohumeral muscular dystrophy.

Journal of the Royal Society, Interface - 6 Jan 2015

Banerji Christopher R S, Knopp Paul, Moyle Louise A, Severini Simone, Orrell Richard W, Teschendorff Andrew E, Zammit Peter S

Abstract excerpt

Facioscapulohumeral muscular dystrophy (FSHD) is an incurable disease, characterized by skeletal muscle weakness and wasting. Genetically, FSHD is characterized by contraction or hypomethylation of repeat D4Z4 units on chromosome 4, which causes aberrant expression of the transcription factor DUX4 from the last repeat. Many genes have been implicated in FSHD pathophysiology, but an integrated molecular model is...

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Share to beta Catenin
Share to Hypoxia-Inducible Factor 1, alpha Subunit

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to MAP Kinase Kinase 4

Share to Muscles

Share to Muscular Dystrophy, Facioscapulohumeral

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Source

Open in PubMed Open full text

Identifiers

PMID: 25551153
DOI: 10.1098/rsif.2014.0797
PMCID: PMC4277075

Genes

DUX4
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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β-Catenin is central to DUX4-driven network rewiring in facioscapulohumeral muscular dystrophy.PMID 25551153Read ↗

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Antagonism Between DUX4 and DUX4c Highlights a Pathomechanism Operating Through β-Catenin in Facioscapulohumeral Muscular DystrophySemantic proximity Read ↗

DUX4 at 25: how it emerged from “junk DNA” to become the cause of facioscapulohumeral muscular dystrophySemantic proximity Read ↗

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