Increased upper airway collapsibility in a mouse model of Marfan syndrome.

doi:10.1016/j.resp.2014.12.013

Article

Increased upper airway collapsibility in a mouse model of Marfan syndrome.

Respiratory physiology & neurobiology - 1 Feb 2015

da Palma Renata Kelly, Farré Ramon, Montserrat Josep Maria, Gorbenko Del Blanco Darya, Egea Gustavo, de Oliveira Luís Vicente Franco, Navajas Daniel, Almendros Isaac

Abstract excerpt

Marfan syndrome (MFS) is a genetic disorder caused by mutations in the FBN1 gene that codifies for fibrilin-1. MFS affects elastic fiber formation and the resulting connective tissue shows abnormal tissue laxity and organization. Although an increased prevalence of obstructive sleep apnea among p...

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Increased upper airway collapsibility in a mouse model of Marfan syndrome.

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