Article
A monolithic glass chip for active single-cell sorting based on mechanical phenotyping.
Lab on a chip - 7 Mar 2015
Faigle Christoph, Lautenschläger Franziska, Whyte Graeme, Homewood Philip, Martín-Badosa Estela, Guck Jochen
Abstract excerpt
The mechanical properties of biological cells have long been considered as inherent markers of biological function and disease. However, the screening and active sorting of heterogeneous populations based on serial single-cell mechanical measurements has not been demonstrated. Here we present a novel monolithic glass chip for combined fluorescence detection and mechanical phenotyping using an optical stretcher. A...
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