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Article

Divergent Targets of Aspergillus fumigatus AcuK and AcuM Transcription Factors during Growth <i>In Vitro</i> versus Invasive Disease

23 Dec 2014

Abstract excerpt

In Aspergillus nidulans, the AcuK and AcuM transcription factors form a complex that regulates gluconeogenesis. In Aspergillus fumigatus, AcuM governs gluconeogenesis and iron acquisition in vitro and virulence in immunosuppressed mice. However, the function of AcuK was previously unknown. Through in vitro studies, we found that A. fumigatus ΔacuK single and ΔacuK ΔacuM double mutants had impaired gluconeogenesis...

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PMID: 25534941
DOI: 10.1128/iai.02685-14

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