Article
Parallel screening for ALK, MET and ROS1 alterations in non-small cell lung cancer with implications for daily routine testing.
Lung cancer (Amsterdam, Netherlands) - 1 Feb 2015
Jurmeister Philipp, Lenze Dido, Berg Erika, Mende Stefanie, Schäper Frank, Kellner Udo, Herbst Hermann, Sers Christine, Budczies Jan, Dietel Manfred, Hummel Michael, von Laffert Maximilian
Abstract excerpt
OBJECTIVES: ALK, MET and ROS1 are prognostic and predictive markers in NSCLC, which need to be implemented in daily routine. To evaluate different detection approaches and scoring systems for optimal stratification of patients eligible for mutation testing in the future, we screened a large and unselected cohort of NSCLCs for all three alterations. MATERIAL AND METHODS: Using tissue microarrays, 473 surgically...
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