Environmental challenge, epigenetic plasticity and the induction of altered phenotypes in mammals.

doi:10.2217/epi.14.51

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Article

Environmental challenge, epigenetic plasticity and the induction of altered phenotypes in mammals.

Epigenomics - 1 Jan 2014

Lillycrop Karen A, Burdge Graham C

Abstract excerpt

The level of transcriptional activity of a gene is regulated by epigenetic processes. There is compelling evidence that environmental challenges throughout the life course can induce phenotypic change. In this review, we summarize the current evidence, focusing specifically on the effects of nutr...

Topics

Animals
DNA Methylation
Disease
Environmental Pollutants
Epigenesis, Genetic
Gene Expression Regulation
Humans
Mammals
Nutritional Status
Phenotype
Risk Factors

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