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Article

β-Lactamase inhibition by avibactam in <i>Mycobacterium abscessus</i>

18 Dec 2014

Abstract excerpt

OBJECTIVES: Two β-lactams, cefoxitin and imipenem, are part of the reference treatment for pulmonary infections with Mycobacterium abscessus. M. abscessus has recently been shown to produce a broad-spectrum β-lactamase, BlaMab, indicating that the combination of β-lactams with a BlaMab inhibitor may improve treatment efficacy. The objectives of this study were to evaluate the impact of BlaMab production on the...

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PMID: 25525201
DOI: 10.1093/jac/dku510

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