Article
Somatic mutations in arachidonic acid metabolism pathway genes enhance oral cancer post-treatment disease-free survival.
Nature communications - 17 Dec 2014
Biswas Nidhan K, Das Subrata, Maitra Arindam, Sarin Rajiv, Majumder Partha P
Abstract excerpt
The arachidonic acid metabolism (AAM) pathway promotes tumour progression. Chemical inhibitors of AAM pathway prolong post-treatment survival of cancer patients. Here we test whether non-synonymous somatic mutations in genes of this pathway, acting as natural inhibitors, increase post-treatment survival. We identify loss-of-function somatic mutations in 15 (18%) of 84 treatment-naïve oral cancer patients by...
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