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Regulation of<i>Helicobacter pylori</i>Virulence Within the Context of Iron Deficiency

11 Dec 2014

Abstract excerpt

Helicobacter pylori strains that harbor the oncoprotein CagA increase gastric cancer risk, and this risk is augmented under iron-deficient conditions. We demonstrate here that iron depletion induces coccoid morphology in strains lacking cagA. To evaluate the stability of augmented H. pylori virulence phenotypes stimulated by low-iron conditions, H. pylori isolated from iron-depleted conditions in vivo were...

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PMID: 25505301
DOI: 10.1093/infdis/jiu805

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