Article
Genotype harmonizer: automatic strand alignment and format conversion for genotype data integration.
BMC research notes - 11 Dec 2014
Deelen Patrick, Bonder Marc Jan, van der Velde K Joeri, Westra Harm-Jan, Winder Erwin, Hendriksen Dennis, Franke Lude, Swertz Morris A
Abstract excerpt
BACKGROUND: To gain statistical power or to allow fine mapping, researchers typically want to pool data before meta-analyses or genotype imputation. However, the necessary harmonization of genetic datasets is currently error-prone because of many different file formats and lack of clarity about which genomic strand is used as reference. FINDINGS: Genotype Harmonizer (GH) is a command-line tool to harmonize...
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