Progesterone receptor gene (PROGINS) polymorphism correlates with late onset of migraine.

doi:10.1089/dna.2014.2534

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Article

Progesterone receptor gene (PROGINS) polymorphism correlates with late onset of migraine.

DNA and cell biology - 1 Mar 2015

Palmirotta Raffaele, Barbanti Piero, Ialongo Cristiano, De Marchis Maria Laura, Alessandroni Jhessica, Egeo Gabriella, Aurilia Cinzia, Fofi Luisa, Valente Maria Giovanna, Ferroni Patrizia, Della-Morte David, Guadagni Fiorella

Abstract excerpt

Progesterone influences central neuronal excitability, a key event in migraine pathophysiology. Progesterone receptor gene (PGR) rs1042838 (G/T - Val660Leu) variant is indicative of PROGINS haplotype and associated to a reduced PGR activity. With the aim of investigating whether any type of association existed between this genetic variant and migraine pathophysiology, genotyping was performed in 380 consecutive...

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Identifiers

PMID: 25494303
DOI: 10.1089/dna.2014.2534
PMCID: PMC4337459

Genes

Variants

rs1042838

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