Feverlike Temperature is a Virulence Regulatory Cue Controlling the Motility and Host Cell Entry of Typhoidal Salmonella

Abstract excerpt

Human infection with typhoidal Salmonella serovars causes a febrile systemic disease, termed enteric fever. Here we establish that in response to a temperature equivalent to fever (39 °C-42 °C) Salmonella enterica serovars Typhi, Paratyphi A, and Sendai significantly attenuate their motility, epithelial cell invasion, and uptake by macrophages. Under these feverlike conditions, the residual epithelial cell...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Salmonella and Campylobacter epidemiology
• Share to Vibrio bacteria research studies
• Share to Viral gastroenteritis research and epidemiology