Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Valosin-containing protein and the pathogenesis of frontotemporal dementia associated with inclusion body myopathy.

Acta neuropathologica - 1 Jul 2007

Guinto Jake B, Ritson Gillian P, Taylor J Paul, Forman Mark S

Abstract excerpt

Frontotemporal dementia with inclusion body myopathy and Paget's disease of bone (IBMPFD) is a rare, autosomal dominant disorder caused by mutations in the gene valosin-containing protein (VCP). The CNS pathology is characterized by a novel pattern of ubiquitin pathology distinct from sporadic and familial frontotemporal lobar degeneration with ubiquitin-positive inclusions without VCP mutations. Yet, the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenosine Triphosphatases
Share to Cell Cycle Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dementia

Share to Inclusion Bodies

Share to Mutation

Share to Myositis, Inclusion Body

Share to Osteitis Deformans

Share to Valosin Containing Protein

Source

Identifiers

PMID: 17457594
DOI: 10.1007/s00401-007-0224-7

Genes

VCP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Valosin-containing protein and the pathogenesis of frontotemporal dementia associated with inclusion body myopathy.PMID 17457594Read ↗

Valosin Containing Protein Associated Fronto-Temporal Lobar Degeneration:Clinical Presentation, Pathologic Features and PathogenesisSemantic proximity Read ↗

The multiple faces of valosin-containing protein-associated diseases: inclusion body myopathy with Paget's disease of bone, frontotemporal dementia, and amyotrophic lateral sclerosis.Semantic proximity Read ↗

Valosin-containing protein disease: inclusion body myopathy with Paget's disease of the bone and fronto-temporal dementia.Semantic proximity Read ↗

[Inclusion body myopathy with Paget's disease of bone and frontotemporal dementia].Semantic proximity Read ↗

TDP-43 in the ubiquitin pathology of frontotemporal dementia with VCP gene mutations.Semantic proximity Read ↗

Inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia is caused by mutant valosin-containing protein.Semantic proximity Read ↗

Autosomal Dominant Inclusion Body Myopathy, Paget Disease of Bone, and Frontotemporal DementiaSemantic proximity Read ↗

Novel ubiquitin neuropathology in frontotemporal dementia with valosin-containing protein gene mutations.Semantic proximity Read ↗

VCP disease associated with myopathy, Paget disease of bone and frontotemporal dementia: review of a unique disorder.Semantic proximity Read ↗

Mutant valosin-containing protein causes a novel type of frontotemporal dementia.Semantic proximity Read ↗

Pathology and genetics of frontotemporal lobar degeneration: an update.Semantic proximity Read ↗

Transgenic mice expressing mutant forms VCP/p97 recapitulate the full spectrum of IBMPFD including degeneration in muscle, brain and boneSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.