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The<i>ctnG</i>gene encodes carbonic anhydrase involved in mycotoxin citrinin biosynthesis from<i>Monascus aurantiacus</i>

7 Dec 2014

Abstract excerpt

Citrinin, a fungal secondary metabolite of polyketide origin, is moderately nephrotoxic to vertebrates, including humans. Citrinin is synthesised by condensation of acetyl-CoA and malonyl-CoA. Six genes involved in the citrinin biosynthesis, including pksCT, ctnA and ctnB, have been cloned in Monascus purpureus. The pksCT gene encodes a polyketide synthase; ctnA is a regulatory factor; and ctnB encodes an...

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PMID: 25482072
DOI: 10.1080/19440049.2014.990993

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