Article
MicroRNA-206 regulates surfactant secretion by targeting VAMP-2.
FEBS letters - 2 Jan 2015
Zhang Honghao, Guo Yujie, Mishra Amarjit, Gou Deming, Chintagari Narendranath Reddy, Liu Lin
Abstract excerpt
Lung surfactant secretion is a highly regulated process. Our previous studies have shown that VAMP-2 is essential for surfactant secretion. In the present study we investigated the role of miR-206 in surfactant secretion through VAMP-2. VAMP-2 was confirmed to be a target of miR-206 by 3'-untranslational region (3'-UTR) luciferase assay. Mutations in the predicated miR-206 binding sites reduced the binding of...
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