Article
Second and third trimester amniotic fluid mesenchymal stem cells can repopulate a de-cellularized lung scaffold and express lung markers.
Journal of pediatric surgery - 1 Nov 2014
Vadasz Stephanie, Jensen Todd, Moncada Camilo, Girard Eric, Zhang Fan, Blanchette Alex, Finck Christine
Abstract excerpt
BACKGROUND/PURPOSE: This study examined the potential of amniotic fluid mesenchymal stem cells (AF-MSCs) to generate lung precursor cells in vitro and on a xenologous three-dimensional de-cellularized lung scaffold. METHODS: AF-MSCs were isolated from human amniotic fluid obtained from 17-37 weeks gestation. Lung differentiation was induced on Matrigel or on de-cellularized rat lungs intra-tracheally injected...
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