Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Sil1, a nucleotide exchange factor for BiP, is not required for antibody assembly or secretion.

Molecular biology of the cell - 1 Feb 2015

Ichhaporia Viraj P, Sanford Tyler, Howes Jenny, Marion Tony N, Hendershot Linda M

Abstract excerpt

Sil1 is a nucleotide exchange factor for the endoplasmic reticulum chaperone BiP, and mutations in this gene lead to Marinesco-Sjögren syndrome (MSS), a debilitating autosomal recessive disease characterized by multisystem defects. A mouse model for MSS was previously produced by disrupting Sil1...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibody Formation
Share to B-Lymphocytes
Share to Cell Line, Transformed

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Endoplasmic Reticulum

Share to Endoplasmic Reticulum Chaperone BiP

Share to Guanine Nucleotide Exchange Factors

Share to Heat-Shock Proteins

Share to Spinocerebellar Degenerations

Source

Open in PubMed Open full text

Identifiers

PMID: 25473114
DOI: 10.1091/mbc.E14-09-1392
PMCID: PMC4310734

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25473114-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Sil1, a nucleotide exchange factor for BiP, is not required for antibody assembly or secretion.PMID 25473114Read ↗

C-terminal mutations destabilize SIL1/BAP and can cause Marinesco-Sjögren syndrome.Semantic proximity Read ↗

Role of the HSP70 Co-Chaperone SIL1 in Health and Disease.Semantic proximity Read ↗

Mutations in SIL1 cause Marinesco-Sjögren syndrome, a cerebellar ataxia with cataract and myopathy.Semantic proximity Read ↗

The nucleotide exchange factor activity of Grp170 may explain the non-lethal phenotype of loss of Sil1 function in man and mouse.Semantic proximity Read ↗

Phenotype-genotype correlations in patients with Marinesco-Sjögren syndrome.Semantic proximity Read ↗

SIL1 mutations and clinical spectrum in patients with Marinesco-Sjogren syndrome.Semantic proximity Read ↗

Myopathy in Marinesco-Sjögren syndrome links endoplasmic reticulum chaperone dysfunction to nuclear envelope pathology.Semantic proximity Read ↗

The gene disrupted in Marinesco-Sjögren syndrome encodes SIL1, an HSPA5 cochaperone.Semantic proximity Read ↗

Novel SIL1 mutations and exclusion of functional candidate genes in Marinesco-Sjögren syndrome.Semantic proximity Read ↗

Loss of function mutations in SIL1 cause Marinesco-Sjögren syndrome.Semantic proximity Read ↗

pERp1 is significantly up-regulated during plasma cell differentiation and contributes to the oxidative folding of immunoglobulin.Semantic proximity Read ↗

Immunological phenotype of the murine Lrba knockoutSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.