Article
Induction of apoptosis in pancreatic cancer cells by vesicular stomatitis virus.
Virology - 1 Jan 2015
Felt Sébastien A, Moerdyk-Schauwecker Megan J, Grdzelishvili Valery Z
Abstract excerpt
Effective oncolytic virus (OV) therapy is dependent on the ability of replication-competent viruses to kill infected cancer cells. We previously showed that human pancreatic ductal adenocarcinoma (PDAC) cell lines are highly heterogeneous in their permissiveness to vesicular stomatitis virus (VSV), in part due to differences in type I interferon (IFN) signaling. Here, using 10 human PDAC cell lines and three...
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