Article
Regulation of hepatocarcinogenesis by microRNAs.
Frontiers in bioscience (Elite edition) - 1 Jan 2013
Wong Chun-Ming, Kai Alan Ka-Lun, Tsang Felice Ho-Ching, Ng Irene Oi-Lin
Abstract excerpt
Liver cancer (hepatocellular carcinoma, HCC) is a major malignancy worldwide. Etiologically, hepatocarcinogenesis is closely associated with HBV and HCV infections; however, its underlying molecular mechanism is not completely understood. MicroRNAs are a class of small non-coding RNAs that negatively regulate gene expression by interacting with the 3'UTR of protein-coding mRNA. MicroRNAs are implicated in nearly...
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