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Article

Overexpression of mutant amyloid-β protein precursor and presenilin 1 modulates enteric nervous system.

Journal of Alzheimer's disease : JAD - 1 Jan 2015

Puig Kendra L, Lutz Brianna M, Urquhart Siri A, Rebel Andrew A, Zhou Xudong, Manocha Gunjan D, Sens MaryAnn, Tuteja Ashok K, Foster Norman L, Combs Colin K

Abstract excerpt

Alzheimer's disease (AD) is a neurodegenerative disorder histologically characterized by amyloid-β (Aβ) protein accumulation and activation of associated microglia. Although these features are well described in the central nervous system, the process and consequences of Aβ accumulation in the enteric nervous system have not been extensively studied. We hypothesized that Aβ also may accumulate in the enteric...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25408221
DOI: 10.3233/JAD-142259
PMCID: PMC6295343

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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