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Ranking the Binding Energies of p53 Mutant Activators and Their ADMET Properties.

Chemical biology & drug design - 1 Aug 2015

Omar Sara Ibrahim, Tuszynski Jack

Abstract excerpt

The guardian of the genome, p53, is the most mutated protein found in all cancer cells. Restoration of wild-type activity to mutant p53 offers promise to eradicate cancer cells using novel pharmacological agents. Several molecules have already been found to activate mutant p53. While the exact mechanism of action of these compounds has not been fully understood, a transiently open pocket has been identified in...

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Identifiers

PMID: 25407396
DOI: 10.1111/cbdd.12480

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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