Immune dysfunction in Rett syndrome patients revealed by high levels of serum anti-N(Glc) IgM antibody fraction.

doi:10.1155/2014/260973

Article

Immune dysfunction in Rett syndrome patients revealed by high levels of serum anti-N(Glc) IgM antibody fraction.

Journal of immunology research - 1 Jan 2014

Papini Anna Maria, Nuti Francesca, Real-Fernandez Feliciana, Rossi Giada, Tiberi Caterina, Sabatino Giuseppina, Pandey Shashank, Leoncini Silvia, Signorini Cinzia, Pecorelli Alessandra, Guerranti Roberto, Lavielle Solange, Ciccoli Lucia, Rovero Paolo, De Felice Claudio, Hayek Joussef

Abstract excerpt

Rett syndrome (RTT), a neurodevelopmental disorder affecting exclusively (99%) female infants, is associated with loss-of-function mutations in the gene encoding methyl-CpG binding protein 2 (MECP2) and, more rarely, cyclin-dependent kinase-like 5 (CDKL5) and forkhead box protein G1 (FOXG1). In this study, we aimed to evaluate the function of the immune system by measuring serum immunoglobulins (IgG and IgM) in...

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