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Article

Elaboration of tubules with active hedgehog drives parenchymal fibrogenesis in gestational alloimmune liver disease.

Human pathology - 1 Jan 2015

Asai Akihiro, Malladi Samyukta, Misch Jonathan, Pan Xiaomin, Malladi Padmini, Diehl Anna Mae, Whitington Peter F

Abstract excerpt

Gestational alloimmune liver disease (GALD) produces severe neonatal liver disease that is notable for paucity of hepatocytes, large numbers of parenchymal tubules, and extensive fibrosis. Liver specimens from 19 GALD cases were studied in comparison with 14 infants without liver disease (normal newborn liver; NNL) to better understand the pathophysiology that would produce this characteristic histopathology....

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Source

Identifiers

PMID: 25387814
DOI: 10.1016/j.humpath.2014.09.010

Genes

KRT19
SPP1
CPS1
EPCAM
GLI2
KRT7
SHH
SOX9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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