Article
Autophagy is a critical regulator of memory CD8(+) T cell formation.
eLife - 11 Nov 2014
Puleston Daniel J, Zhang Hanlin, Powell Timothy J, Lipina Elina, Sims Stuart, Panse Isabel, Watson Alexander S, Cerundolo Vincenzo, Townsend Alain Rm, Klenerman Paul, Simon Anna Katharina
Abstract excerpt
During infection, CD8(+) T cells initially expand then contract, leaving a small memory pool providing long lasting immunity. While it has been described that CD8(+) T cell memory formation becomes defective in old age, the cellular mechanism is largely unknown. Autophagy is a major cellular lysosomal degradation pathway of bulk material, and levels are known to fall with age. In this study, we describe a novel...
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