Article
Diet-induced obesity does not impact the generation and maintenance of primary memory CD8 T cells.
Journal of immunology (Baltimore, Md. : 1950) - 15 Dec 2014
Khan Shaniya H, Hemann Emily A, Legge Kevin L, Norian Lyse A, Badovinac Vladimir P
Abstract excerpt
The extent to which obesity compromises the differentiation and maintenance of protective memory CD8 T cell responses and renders obese individuals susceptible to infection remains unknown. In this study, we show that diet-induced obesity did not impact the maintenance of pre-existing memory CD8 T cells, including acquisition of a long-term memory phenotype (i.e., CD27(hi), CD62L(hi), KLRG1(lo)) and function...
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