Article
PD-L1 expression in melanocytic lesions does not correlate with the BRAF V600E mutation.
Cancer immunology research - 1 Feb 2015
Rodić Nemanja, Anders Robert A, Eshleman James R, Lin Ming-Tseh, Xu Haiying, Kim Jung H, Beierl Katie, Chen Shuming, Luber Brandon S, Wang Hao, Topalian Suzanne L, Pardoll Drew M, Taube Janis M
Abstract excerpt
PD-L1 expression in melanoma correlates with response to PD-1 pathway-blocking antibodies. Aberrant tumor-cell PD-L1 expression may be oncogene driven and/or induced by IFNγ. Melanomas express PD-L1 in association with tumor-infiltrating lymphocytes (TIL), but the potential contribution of the BRAF V600E mutation (BRAFmut) to induced PD-L1 expression has not been determined. Fifty-two archival melanocytic lesions...
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