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Article

FHL2 expression and variants in hypertrophic cardiomyopathy

30 Oct 2014

Abstract excerpt

Based on evidence that FHL2 (four and a half LIM domains protein 2) negatively regulates cardiac hypertrophy we tested whether FHL2 altered expression or variants could be associated with hypertrophic cardiomyopathy (HCM). HCM is a myocardial disease characterized by left ventricular hypertrophy, diastolic dysfunction and increased interstitial fibrosis and is mainly caused by mutations in genes coding for...

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PMID: 25358972
DOI: 10.1007/s00395-014-0451-8

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