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Zinc Finger Nucleases Targeting the Human Papillomavirus E7 Oncogene Induce E7 Disruption and a Transformed Phenotype in HPV16/18-Positive Cervical Cancer Cells

22 Oct 2014

Abstract excerpt

PURPOSE: Cervical cancer is mainly caused by infections of high-risk human papillomavirus (HR-HPV). Persistent expression of HR-HPV oncogenes E6 and E7 is implicated in malignant transformation. The aim was to provide proof-of-concept data to support use of zinc finger nucleases (ZFN) targeting HPV E7 to treat HPV-related cervical cancer. EXPERIMENTAL DESIGN: We designed and constructed ZFNs that could...

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PMID: 25336692
DOI: 10.1158/1078-0432.ccr-14-0250

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