Article
Understanding the mechanism of atovaquone drug resistance in Plasmodium falciparum cytochrome b mutation Y268S using computational methods.
PloS one - 1 Jan 2014
Akhoon Bashir A, Singh Krishna P, Varshney Megha, Gupta Shishir K, Shukla Yogeshwar, Gupta Shailendra K
Abstract excerpt
The rapid appearance of resistant malarial parasites after introduction of atovaquone (ATQ) drug has prompted the search for new drugs as even single point mutations in the active site of Cytochrome b protein can rapidly render ATQ ineffective. The presence of Y268 mutations in the Cytochrome b (Cyt b) protein is previously suggested to be responsible for the ATQ resistance in Plasmodium falciparum (P....
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