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Article

Suvanine sesterterpenes from a tropical sponge Coscinoderma sp. inhibit isocitrate lyase in the glyoxylate cycle.

Marine drugs - 10 Oct 2014

Lee So-Hyoung, Won Tae Hyung, Kim Heegyu, Ahn Chan-Hong, Shin Jongheon, Oh Ki-Bong

Abstract excerpt

The glyoxylate cycle is a sequence of anaplerotic reactions catalyzed by the key enzymes isocitrate lyase (ICL) and malate synthase (MLS). Mutants of Candida albicans lacking ICL are markedly less virulent in mice than the wild-type. Suvanine sesterterpenes (1-9) isolated from a tropical sponge Coscinoderma sp. were evaluated for their inhibitory activities toward recombinant ICL from C. albicans. These studies...

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Identifiers

PMID: 25310766
DOI: 10.3390/md12105148
PMCID: PMC4210890

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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