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Article

Selective serotonin reuptake inhibitor exposure alters osteoblast gene expression and craniofacial development in mice

12 Oct 2014

Abstract excerpt

BACKGROUND: Selective serotonin reuptake inhibitor (SSRI) use in pregnancy has been linked to craniofacial birth defects. Little is known about the effects of serotonin or SSRIs on craniofacial development. Here, we provide evidence that citalopram (SSRI) alters the osteogenic profile of murine calvarial cells and leads to craniofacial dysmorphology. METHODS: We used mouse calvarial pre-osteoblast cells...

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PMID: 25308507
DOI: 10.1002/bdra.23323

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