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Article

'N-of-1-pathways' unveils personal deregulated mechanisms from a single pair of RNA-Seq samples: towards precision medicine.

Journal of the American Medical Informatics Association : JAMIA - 1 Jan 2000

Gardeux Vincent, Achour Ikbel, Li Jianrong, Maienschein-Cline Mark, Li Haiquan, Pesce Lorenzo, Parinandi Gurunadh, Bahroos Neil, Winn Robert, Foster Ian, Garcia Joe G N, Lussier Yves A

Abstract excerpt

BACKGROUND: The emergence of precision medicine allowed the incorporation of individual molecular data into patient care. Indeed, DNA sequencing predicts somatic mutations in individual patients. However, these genetic features overlook dynamic epigenetic and phenotypic response to therapy. Meanwhile, accurate personal transcriptome interpretation remains an unmet challenge. Further, N-of-1 (single-subject)...

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Identifiers

PMID: 25301808
DOI: 10.1136/amiajnl-2013-002519
PMCID: PMC4215042

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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