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Article

Association between acquired resistance to PLX4032 (vemurafenib) and ATP-binding cassette transporter expression.

BMC research notes - 10 Oct 2014

Michaelis Martin, Rothweiler Florian, Nerreter Thomas, van Rikxoort Marijke, Zehner Richard, Dirks Wilhelm G, Wiese Michael, Cinatl Jindrich

Abstract excerpt

BACKGROUND: Various kinase inhibitors are known to be ATP-binding cassette (ABC) transporter substrates and resistance acquisition to kinase inhibitors has been associated to increased ABC transporter expression. Here, we investigated the role of the ABC transporters ABCB1, ABCC1, and ABCG2 during melanoma cell resistance acquisition to the V600-mutant BRAF inhibitors PLX4032 (vemurafenib) and PLX4720. PLX4032...

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Topics

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Share to ATP Binding Cassette Transporter, Subfamily B
Share to ATP Binding Cassette Transporter, Subfamily G, Member 2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to ATP-Binding Cassette Transporters

Share to Drug Resistance, Multiple

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Source

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Identifiers

PMID: 25300205
DOI: 10.1186/1756-0500-7-710
PMCID: PMC4197243

Genes

ABCB1
ABCG2
ABCC1
BRAF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association between acquired resistance to PLX4032 (vemurafenib) and ATP-binding cassette transporter expression.PMID 25300205Read ↗

Overexpression of ATP-binding cassette transporter ABCG2 as a potential mechanism of acquired resistance to vemurafenib in BRAF(V600E) mutant cancer cells.Semantic proximity Read ↗

Differential expression of ABCB5 in BRAF inhibitor-resistant melanoma cell linesSemantic proximity Read ↗

Identification of MET and SRC activation in melanoma cell lines showing primary resistance to PLX4032.Semantic proximity Read ↗

ABCB8 Mediates Doxorubicin Resistance in Melanoma Cells by Protecting the Mitochondrial GenomeSemantic proximity Read ↗

Pharmacodynamic Characterization of the Efficacy Signals Due to Selective BRAF Inhibition with PLX4032 in Malignant MelanomaSemantic proximity Read ↗

Interaction of Tyrosine Kinase Inhibitors with the MDR-Related ABC Transporter ProteinsSemantic proximity Read ↗

Mapping ATP-binding cassette transporter gene expression profiles in melanocytes and melanoma cellsSemantic proximity Read ↗

Adaptive upregulation of FOXD3 and resistance to PLX4032/4720-induced cell death in mutant B-RAF melanoma cells.Semantic proximity Read ↗

Human drug efflux transporter ABCC5 confers acquired resistance to pemetrexed in breast cancerSemantic proximity Read ↗

PBK/TOPK inhibitor OTS964 resistance is mediated by ABCB1-dependent transport function in cancer: in vitro and in vivo studySemantic proximity Read ↗

Mutant Gly482 and Thr482 ABCG2 mediate high-level resistance to lipophilic antifolates.Semantic proximity Read ↗

Differential sensitivity of melanoma cell lines with BRAFV600E mutation to the specific Raf inhibitor PLX4032.Semantic proximity Read ↗

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