Article
Soy isoflavones have antimutagenic activity on DNA damage induced by the antileishmanial Glucantime (meglumine antimoniate).
Drug and chemical toxicology - 1 Jan 2015
Cantanhêde Ludymila Furtado, Almeida Laís Pinheiro, Soares Rossy-Eric Pereira, Castelo Branco Patrícia Valéria Gomes, Pereira Silma Regina Ferreira
Abstract excerpt
Isoflavones are phytoestrogens reported to be potent antioxidant agents. In contrast, the antileishmanial meglumine antimoniate has mutagenic activities. This study evaluated the ability of soy isoflavones to reduce DNA damage induced by meglumine antimoniate. Antimutagenic effects (by micronucleus test) were tested using Swiss mice divided into seven groups treated with meglumine antimoniate (425 mg/kg bw...
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