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Article

Characterization of Niphatenones that Inhibit Androgen Receptor N-Terminal Domain

30 Sept 2014

Abstract excerpt

Androgen ablation therapy causes a temporary reduction in tumor burden in patients with advanced prostate cancer. Unfortunately the malignancy will return to form lethal castration-recurrent prostate cancer (CRPC). The androgen receptor (AR) remains transcriptionally active in CRPC in spite of castrate levels of androgens in the blood. AR transcriptional activity resides in its N-terminal domain (NTD). Possible...

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PMID: 25268119
DOI: 10.1371/journal.pone.0107991

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