Article
Mast cells control the expansion and differentiation of IL-10-competent B cells.
Journal of immunology (Baltimore, Md. : 1950) - 1 Nov 2014
Mion Francesca, D'Incà Federica, Danelli Luca, Toffoletto Barbara, Guarnotta Carla, Frossi Barbara, Burocchi Alessia, Rigoni Alice, Gerdes Norbert, Lutgens Esther, Tripodo Claudio, Colombo Mario P, Rivera Juan, Vitale Gaetano, Pucillo Carlo E
Abstract excerpt
The discovery of B cell subsets with regulatory properties, dependent on IL-10 production, has expanded our view on the mechanisms that control inflammation. Regulatory B cells acquire the ability to produce IL-10 in a stepwise process: first, they become IL-10 competent, a poised state in which B cells are sensitive to trigger signals but do not actually express the Il-10 gene; then, when exposed to appropriate...
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