Cellular immune responses in hemophilia: why do inhibitors develop in some, but not all hemophiliacs?

Abstract excerpt

Advances in molecular immunology over the past two decades permit a better understanding of why antibodies develop to peptide antigens like factor VIII and the events that lead to the development of these antibodies. Two important variables that are critical in antibody formation are (i) the molecular defect in FVIII and the consequences of that defect on translation and protein production, and (ii) the major...

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