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Article

Enhanced fitness of adult spermatogonial stem cells bearing a paternal age-associated FGFR2 mutation.

Stem cell reports - 12 Aug 2014

Martin Laura A, Assif Nicholas, Gilbert Moses, Wijewarnasuriya Dinali, Seandel Marco

Abstract excerpt

Pathogenic de novo mutations increase with fathers' age and could be amplified through competition between genetically distinct subpopulations of spermatogonial stem cells (SSCs). Here, we tested the fitness of SSCs bearing wild-type human FGFR2 or an Apert syndrome mutant, FGFR2 (S252W), to provide experimental evidence for SSC competition. The S252W allele conferred enhanced FGFR2-mediated signaling,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25254335
DOI: 10.1016/j.stemcr.2014.06.007
PMCID: PMC4176532

Genes

FGFR2
GDNF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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