Article
A random set scoring model for prioritization of disease candidate genes using protein complexes and data-mining of GeneRIF, OMIM and PubMed records.
BMC bioinformatics - 24 Sept 2014
Jiang Li, Edwards Stefan M, Thomsen Bo, Workman Christopher T, Guldbrandtsen Bernt, Sørensen Peter
Abstract excerpt
BACKGROUND: Prioritizing genetic variants is a challenge because disease susceptibility loci are often located in genes of unknown function or the relationship with the corresponding phenotype is unclear. A global data-mining exercise on the biomedical literature can establish the phenotypic profile of genes with respect to their connection to disease phenotypes. The importance of protein-protein interaction...
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