Article
[Protective properties of recombinant IgA1 protease from meningococcus].
Biomeditsinskaia khimiia - 1 Jan 2000
Kotel'nikova O V, Alliluev A P, Drozhzhina E Iu, Koroleva I S, Sitnikova E A, Zinchenko A A, Gordeeva E A, Melikhova T D, Nokel' E A, Zhigis L S, Zueva V S, Razguliaeva O A, Serova O V, Iagudaeva E Iu, Rumsh L D
Abstract excerpt
The study of enzymatic and protective properties of recombinant IgA1 protease in active and mutant form showed that active form of IgA1 protease exhibited species - and type-specificity for mouse and human immunoglobulins. Mutant form, which did not exhibit enzymatic activity, had protective properties against meningococcal infection, induced by meningococcus serogroup A, B and C protecting the mice from lethal...
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