Article
Progressive hyperpigmentation in a Taiwanese child due to an inborn error of vitamin B12 metabolism (cblJ).
The British journal of dermatology - 1 Apr 2015
Takeichi T, Hsu C-K, Yang H-S, Chen H-Y, Wong T-W, Tsai W-L, Chao S-C, Lee J Y-Y, Akiyama M, Simpson M A, McGrath J A
Abstract excerpt
The physiology of human skin pigmentation is varied and complex, with an extensive melanogenic paracrine network involving mesenchymal and epithelial cells, contributing to the regulation of melanocyte survival and proliferation and melanogenesis. Mutations in several genes, involving predominantly the KIT ligand/c-Kit and Ras/mitogen-activated protein kinase signalling pathways, have been implicated in a...
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