Article
Effect of functional nuclear factor-kappaB genetic polymorphisms on hepatitis B virus persistence and their interactions with viral mutations on the risk of hepatocellular carcinoma.
Annals of oncology : official journal of the European Society for Medical Oncology - 1 Dec 2014
Zhang Q, Ji X W, Hou X M, Lu F M, Du Y, Yin J H, Sun X Y, Deng Y, Zhao J, Han X, Yang G S, Zhang H W, Chen X M, Shen H B, Wang H Y, Cao G W
Abstract excerpt
BACKGROUND: Nonresolving inflammation and viral mutations are important in hepatitis B virus (HBV)-induced hepatocarcinogenesis. However, the effects of genetic polymorphisms affecting nuclear factor-kappaB (NF-κB) on HBV persistence and generation of hepatocellular carcinoma (HCC)-related HBV mutations remain unknown. PATIENTS AND METHODS: rs28362491 (NFKB1 -94Ins > Del), rs2233406 (NFKBIA -826C > T), rs3138053...
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