Article
Identification of a NFKBIA polymorphism associated with lower NFKBIA protein levels and poor survival outcomes in patients with glioblastoma multiforme.
International journal of molecular medicine - 1 Nov 2014
Zhao Zhaohui, Zhong Xingming, Wu Tinfeng, Yang Tianquan, Chen Guilin, Xie Xueshun, Wei Yongxin, Ye Ming, Zhou Youxin, Du Ziwei
Abstract excerpt
The aberrant constitutive activation of nuclear factor-κB (NF-κB) has been observed in glioblastomas, while NF-κB inhibitor alpha (NFKBIA) inhibits the NF-κB signaling pathway under several physiological processes. However, the contribution of NFKBIA to glioblastomas is poorly understood. In the present study, using gene sequencing, we identified rs1957106 as a novel single nucleotide polymorphism (SNP) in NFKBIA...
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