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Article

Aaptamine, a spongean alkaloid, activates p21 promoter in a p53-independent manner.

Biochemical and biophysical research communications - 31 Mar 2006

Aoki Shunji, Kong Dexin, Suna Hideaki, Sowa Yoshihiro, Sakai Toshiyuki, Setiawan Andi, Kobayashi Motomasa

Abstract excerpt

Aaptamine, a benzonaphthyridine alkaloid was isolated from a marine sponge on the guidance of a bioassay using the transfected human osteosarcoma MG63 cells (MG63luc(+)). Aaptamine activated p21 promoter stably transfected in MG63 cells dose-dependently at the concentrations of 20-50microM. Expression of p21 and its mRNA in the wild-type MG63 cells also increased by aaptamine-treatment. Furthermore, the cell...

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PMID: 16480688
DOI: 10.1016/j.bbrc.2006.01.119

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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