Article
Higher risk of aggressive pancreatic neuroendocrine tumors in MEN1 patients with MEN1 mutations affecting the CHES1 interacting MENIN domain.
The Journal of clinical endocrinology and metabolism - 1 Nov 2014
Bartsch Detlef K, Slater Emily P, Albers Max, Knoop Richard, Chaloupka Brunhilde, Lopez Caroline L, Fendrich Volker, Kann Peter H, Waldmann Jens
Abstract excerpt
CONTEXT: Sixty to 80% of multiple endocrine neoplasia type 1 (MEN1) patients develop pancreatic neuroendocrine neoplasias (pNENs), which reveal an aggressive behavior in 10%-20% of patients. Causative MEN1 mutations in the interacting domains of the encoded Menin protein directly alter its regulation abilities and may influence the phenotype. OBJECTIVE: The objective of the study was the evaluation of an...
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