Article
Higher risk of death among MEN1 patients with mutations in the JunD interacting domain: a Groupe d'etude des Tumeurs Endocrines (GTE) cohort study.
Human molecular genetics - 15 May 2013
Thevenon Julien, Bourredjem Abderrahmane, Faivre Laurence, Cardot-Bauters Catherine, Calender Alain, Murat Arnaud, Giraud Sophie, Niccoli Patricia, Odou Marie-Françoise, Borson-Chazot Françoise, Barlier Anne, Lombard-Bohas Catherine, Clauser Eric, Tabarin Antoine, Parfait Béatrice, Chabre Olivier, Castermans Emilie, Beckers Albert, Ruszniewski Philippe, Le Bras Morgane, Delemer Brigitte, Bouchard Philippe, Guilhem Isabelle, Rohmer Vincent, Goichot Bernard, Caron Philippe, Baudin Eric, Chanson Philippe, Groussin Lionel, Du Boullay Hélène, Weryha Georges, Lecomte Pierre, Penfornis Alfred, Bihan Hélène, Archambeaud Françoise, Kerlan Véronique, Duron Françoise, Kuhn Jean-Marc, Vergès Bruno, Rodier Michel, Renard Michel, Sadoul Jean-Louis, Binquet Christine, Goudet Pierre
Abstract excerpt
Multiple endocrine neoplasia syndrome type 1 (MEN1), which is secondary to mutation of the MEN1 gene, is a rare autosomal-dominant disease that predisposes mutation carriers to endocrine tumors. Although genotype-phenotype studies have so far failed to identify any statistical correlations, some families harbor recurrent tumor patterns. The function of MENIN is unclear, but has been described through the...
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