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Avian pathogenic Escherichia coli ΔtonB mutants are safe and protective live-attenuated vaccine candidates.

Veterinary microbiology - 10 Oct 2014

Holden Karen M, Browning Glenn F, Noormohammadi Amir H, Markham Philip, Marenda Marc S

Abstract excerpt

Avian pathogenic Escherichia coli (APEC) cause colibacillosis, a serious respiratory disease in poultry. Most APEC strains possess TonB-dependent outer membrane transporters for the siderophores salmochelin and aerobactin, which both contribute to their capacity to cause disease. To assess the potential of iron transport deficient mutants as vaccine candidates, the tonB gene was deleted in the APEC wild type...

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PMID: 25205199
DOI: 10.1016/j.vetmic.2014.07.028

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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