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Article

Activation of p53 by sodium selenite switched human leukemia NB4 cells from autophagy to apoptosis.

Oncology research - 1 Jan 2013

Li Zhushi, Shi Kejian, Guan Liying, Jiang Qian, Yang Yang, Xu Caimin

Abstract excerpt

It was revealed by our previous research that sodium selenite repressed autophagy accompanied by the induction of apoptosis in human leukemia NB4 cells. The inhibition of autophagy exerted a facilitative effect on apoptosis. In the present study, we further explored the mechanisms underlying the switch from autophagy to apoptosis and elucidated p53 played a key role. Selenite induced phosphorylation of p53 at the...

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Identifiers

PMID: 25198662
DOI: 10.3727/096504014X14024160459087

Genes

MDM2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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