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Article

Direct regulation of GAS6/AXL signaling by HIF promotes renal metastasis through SRC and MET.

Proceedings of the National Academy of Sciences of the United States of America - 16 Sept 2014

Rankin Erinn B, Fuh Katherine C, Castellini Laura, Viswanathan Kartik, Finger Elizabeth C, Diep Anh N, LaGory Edward L, Kariolis Mihalis S, Chan Andy, Lindgren David, Axelson Håkan, Miao Yu R, Krieg Adam J, Giaccia Amato J

Abstract excerpt

Dysregulation of the von Hippel-Lindau/hypoxia-inducible transcription factor (HIF) signaling pathway promotes clear cell renal cell carcinoma (ccRCC) progression and metastasis. The protein kinase GAS6/AXL signaling pathway has recently been implicated as an essential mediator of metastasis and receptor tyrosine kinase crosstalk in cancer. Here we establish a molecular link between HIF stabilization and...

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Topics

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Share to Axl Receptor Tyrosine Kinase
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hepatocyte Growth Factor

Share to Hypoxia-Inducible Factor 1, alpha Subunit

Share to Proto-Oncogene Mas

Share to Proto-Oncogene Proteins c-met

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Share to Von Hippel-Lindau Tumor Suppressor Protein

Source

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Identifiers

PMID: 25187556
DOI: 10.1073/pnas.1404848111
PMCID: PMC4169907

Genes

AXL
GAS6
MET
SRC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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