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Article

Anomalous altered expressions of downstream gene-targets in TP53-miRNA pathways in head and neck cancer.

Scientific reports - 4 Sept 2014

Mitra Sanga, Mukherjee Nupur, Das Smarajit, Das Pijush, Panda Chinmay Kumar, Chakrabarti Jayprokas

Abstract excerpt

The prevalence of head and neck squamous cell carcinoma, HNSCC, continues to grow. Change in the expression of TP53 in HNSCC affects its downstream miRNAs and their gene targets, anomalously altering the expressions of the five genes, MEIS1, AGTR1, DTL, TYMS and BAK1. These expression alterations follow the repression of TP53 that upregulates miRNA-107, miRNA- 215, miRNA-34 b/c and miRNA-125b, but downregulates...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25186767
DOI: 10.1038/srep06280
PMCID: PMC5385823

Genes

AGTR1
BAK1
DTL
MEIS1
TYMS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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